By Michael Goodfellow (Eds.)
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Extra info for Actinomycetes in Biotechnology
ANTIBIOTIC RESISTANCE Antibiotic-producing actinomycetes generally possess the target of their own antibiotics but have self-resistance mechanisms for them to survive in the presence of the antibiotics they produce (Demain, 1974; Vining, 1979). Consequently, self-resistance has been regarded as an essential factor for antibiotic production. In fact, high-yielding antibiotic strains have been obtained by generating and selecting clones or mutants with higher levels of self-resistance than that of the parental strains (Katagiri, 1954; Unowsky and Hoppe, 1978; Crameri and Davies, 1986).
D e B r o s s e , C , Heald, S. L. and Fisher, R. (1986). Structure of aridicin A . A n integrated approach employing 2 D N M R , energy minimisation and distance constraints. Journal of the American Chemical Society 108, 3063-3075. Jensen, H. L. (1928). sp—a group of acidophilus actinomycetes isolated from the soil. Soil Science 25, 225-233. Kahn, M. R. and Williams, S. T. (1975). Studies on the ecology of actinomycetes in soil. VIII. Distribution and characteristics of acidophilic actinomycetes in soil.
1986). Tiacumicins, a novel series of 18-membered macrolide antibiotics. II. Isolation and elucidation of structures. 26th Interscience Congress on Antimicrobial Agents and Chemotherapy, Abstract 937. , Kanbayashi, N . , Aoyagi, T. and U m e z a w a , H. (1980). Effect of bestatin on mouse immune system and experimental murine tumors. Journal of Antibiotics 3 3 , 642-652. Ishizuka, M . , Masuda, T . , M o m o s e , A . , Takeuchi, T. and U m e z a w a , H. (1982). Studies on effects of forphenicol on immune responses.
Actinomycetes in Biotechnology by Michael Goodfellow (Eds.)