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By J.H.U. Brown, James Francis Dickson

ISBN-10: 0120049058

ISBN-13: 9780120049059

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In the steady state most of the reactions involved in drug metabolism obey MichaelisMenten kinetics, at least approximately: Reaction rate = 7 mmaa x c ^ (3) where C is the concentration of the drug at the reaction site, and VmSiX and Km are constants of the reaction. Dedrick et al. (1972) have shown that when these constants are determined in vitro they may be used successfully to fit models to in vivo pharmacokinetic data. The chief processes affecting the transport of a drug from its portal of entry into the body to its receptors are described in the following sections.

21, 201. Shaw, J. , and Michaels, A. (1974). In "Relevance of Animal Models" (H. ). Churchill, Livingstone, London. In press. Shell, J. , and Baker, R. W. (1974). Ann. Ophthalmol. 6, 1037. Soeldner, J. , Chang, K. , and Hiebert, J. M. (1973). In "Temporal Aspects of Therapeutics" (J. Urquhart and Γ. E. ), ALZA Conference Series, Vol. 2, p. 181. Plenum, New York. Spaeth, G. L. (1970). Invest. Ophthalmol. 9, 73. , and Fritsch, W. (1964). Arch. Dermatol. 90, 512. Tatum, H. (1972). Amer. J. Obstet.

Bischoff, K. , Dedrick, R. , Zaharko, D. , and Longstreth, J. A. (1971). J. Pharm. Sci. 60, 1128. Blackwell, B. (1972). Clin. Pharmacol. Ther. 13, 841. Buckles, R. , and Wong, P. (1974). Acad. Pharm. Sci. Abstr. 4, 37. Coe, R. 0 , and Bull, F . E. (1968). / . Amer. Med. Ass. 206, 1515. David, D . , and Berkowitz, J. S. (1969). Lancet ii, 149. Davison, C. (1971). In "Fundamentals on Drug Metabolism and Drug Disposition" (B. La Der, G. Mandel, and E. ), p. 63. Williams & Wilkins, Baltimore, Maryland.

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Advances in Biomedical Engineering. Volume 5 by J.H.U. Brown, James Francis Dickson


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