By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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Extra info for Advances in Cancer Research, Vol. 15
S . BUTEL, S . S. TEVETHIA, AND J. L. MELNICK lines were fused in the presence of monkey kidney cells. It was postulated that this rescue occurred because the transforming genomes were defective a t different loci. However, the rescued progeny were not characterized to reveal whether this rescue was a consequence of complementation or of recombination of the defective genomes. If complementation, one would expect the yield of rescued progeny to be a mixture of defective viruses unable to replicate independently.
Similar reactivity was detected using the immunofluorescence test. On the basis of adsorption studies, it was concluded that normal cell antigens cross-reacted with the SV40 antigen. However, complete absorption of anti-S activity from the sera using either SV40-transformed cells or trypsin-treated nontransformed cells was not achieved. Burger (1969) has described presumably “tumor-specific” sites a t the surface of SV40-transformed cells. The sites were demonstrated by an agglutination test, using agglutinin isolated from wheat germ lipase.
I n line with this reasoning, it would be interesting to know whether SV40 can be rescued, and how readily, from transformed xeroderma pigmentosum cells which appear to be deficient in the enzyme(s) involved in host cell reactivation (Aaronson and Lytle, 1970) since these might be the enzymes involved in excision of the integrated viral genome. Single cell clones have been isolated from many SV40-transformed cell lines. , 1967). These studies revealed that nearly every SV40transformed cell contained the complete viral genome.
Advances in Cancer Research, Vol. 15 by George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)