By Sara Fuchs (auth.), W. Arber, S. Falkow, W. Henle, P. H. Hofschneider, J. H. Humphrey, J. Klein, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syruĉek, P. K. Vogt (eds.)
The learn of the genetic law of immune reaction to traditional multidetermi nant immunogens was once undertaken via the strategy of bidirectional selective breed ing of excessive or Low antibody responder strains of mice. 5 choices are defined: choice I, conducted for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in each one iteration. choice II, conducted for agglutinin responsiveness to sheep erythrocytes repeated in each one iteration. choice III and choice IV played respectively for agglutinin reaction to flagellar or somatic antigens of Salmonella typhimurium and Salmonella oranienburg alternated in each one new release. choice V, played for passive agglutinin reaction to bovine serum albumin and rabbit gamma globulin alternated in each one new release. In every one choice the nature investigated is polygenic. low and high responder strains diverge gradually through the selective breeding. The maximal interline separation (selection restrict) is reached within the 7th-16th generations. low and high responder strains at choice restrict are thought of homozygous for the nature submitted to se~ection. Their variance is for this reason in simple terms as a result of environ psychological results. the adaptation in agglutinin titre among low and high strains is 220-fold in choice I, 103-fold in choice II, 90-fold in choice III, 85-fold in choice IV and 275-fold in choice V. The partition of genetic and environmental variances within the origin popu lations of the 5 decisions is tested. the share of genetic variance is 60% in choice I; forty nine% in choice II; fifty one% in choice III; forty seven% in choice IV and seventy six% in choice V.
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The examine of the genetic legislation of immune reaction to typical multidetermi nant immunogens was once undertaken through the tactic of bidirectional selective breed ing of excessive or Low antibody responder traces of mice. 5 decisions are defined: choice I, conducted for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in every one new release.
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Extra info for Current Topics in Microbiology and Immunology
83 85 86 88 88 90 91 91 91 92 92 93 94 95 I. Introduction The complex and potent system of mammalian immunity has been produced by natural selection, through the progressive improvement of the less efficient mechanisms of more primitive animals. The teleonomic function of the immunity system that has directed its evolution, is the self-protection against invasion by viruses, bacteria, parasites (anti-infection immunity) and possibly by transformed malignant cells (anti-tumour immunity).
J. Med. : Myasthenia gravis: a new hypothesis. Scot. Med. J. : Immunological characterization of the cholinergic receptor protein from Electrophorus electricus. S. Lett. : Animal model for myasthenia gravis: acetylcholine receptor-induced myasthenia in rabbits, guinea pigs and monkeys. Isr. J. Med. Sci. : Passive transfer of experimental autoimmune myasthenia by lymph node cells in inbred guinea pigs. J. Exp. Med. : Experimental autoimmune myasthenia gravis induced in monkeys by purified acetylcholine receptor.
1. Selective Breeding and Genetic Analysis. . . . . . . . 2. Kinetics of Primary and Secondary Antibody Responses to BSA and RGG E. Comparison of the Results of the Five Selections . IV. Non-Specific Effect of Selective Breeding. A. Selection I . . . . . . 1. Salmonella Typhimurium Antigens 2. Bovine Serum Albumin . 3. Hen Egg Albumin B. Selection II C. Selections III and IV . D. Selection V. . . V. Cellular Expression and Functions of the Genes Regulating the Quantitative Antibody Response .
Current Topics in Microbiology and Immunology by Sara Fuchs (auth.), W. Arber, S. Falkow, W. Henle, P. H. Hofschneider, J. H. Humphrey, J. Klein, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syruĉek, P. K. Vogt (eds.)